February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Selection
of clinical trial design is iterative, involving scientists,
statisticians, management, and regulators
Encourage use of
measures with scientific meaning
Facilitate search
through extensive space of designs
Facilitate
comparison of designs with respect to variety of operating
characteristics
Seamless
progression from design to monitoring to analysis