February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Session 2
Group Sequential
Stopping Rules
Families of
Designs
Evaluation of Group
Sequential Designs
Case Study: Group sequential
design
·Two sample comparison of proportions
Practicum: Basic design using GUI
·Probability models & hypotheses
·Power and sample size determination
·Evaluation of candidate designs