February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Session 3
Issues in
Implementing Stopping Rules
Recomputation of
Sample Size
Constraining
Boundaries at Prior Analyses
Monitoring Secondary
Endpoints
Case Study: Monitoring a clinical
trial
·Boundary scales: Unified family versus error spending functions
·Re-estimation of sample size