February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Session 1- Overview: 52
Statistical Issues
The stopping rule must account for ethical issues.
Early stopping might be based on
·Individual ethics
-the observed statistic suggests efficacy
-the observed statistic suggests harm
·Group ethics
-the observed statistic suggests equivalence
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Exact choice will vary according to scientific / clinical setting