February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Session
1- Fixed Sample Design:
108
Case Study: Statistical Design Issues
Defining the statistical hypotheses
Null hypothesis
·
No difference in mortality between groups
·
Estimated baseline rate
-
14 day mortality: 30%
-
(needed for estimates of variability)