February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Session 1- Fixed Sample Design: 102
Case Study: Statistical Design Issues
Refining the primary endpoint (cont.)
Time to death (censored continuous data)
·
·Would have heavy early censoring due to logistical constraints of trauma centers
·
·Might place emphasis on clinically meaningless improvements in very short term survival
-e.g., can detect differences in 1 day survival even if no difference at 10 days