February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Session 1- Fixed Sample Design: 104
Case Study: Statistical Design Issues
Refining the primary endpoint (cont.)
Time alive out of ICU during fixed period of time (continuous data)
·Incorporates morbidity endpoints
·
·May be sensitive to clinically meaningless improvements depending upon time frame chosen