February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Session 1- Fixed Sample Design: 79
Criteria for sample size (cont.)
Special case: Censored survival studies
·Statistical information proportional to number of events
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·Sample size computations for desired number of events
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·Additional probability models used to account for accrual and follow-up patterns
Determining the Sample Size