February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Session 1- Fixed Sample Design: 38
Statistical Hypotheses: Summary Measure
Choice of summary measure greatly affects the scientific relevance of the trial
Summary measure should be chosen based on (in order of importance)
·Current state of scientific knowledge
·Most clinically relevant summary measure
·Summary measure most likely to be affected by the intervention
·Summary measure affording the greatest statistical precision