February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Session 1- Fixed Sample Design: 91
Evaluation of Fixed Sample Designs
Sensitivity to assumptions about variability
Comparison of means, geometric means
·Need to estimate variability of observations
·
Comparison of proportions, odds, rates
·Need to estimate event rate
·
Comparison of hazards
·Need to estimate number of subjects and time required to observe required number of events