February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Session 1-
Fixed Sample Design: 65
Example: Two arm comparison of means
One-sided equivalence test
·Null: Mean of 0 in each group
-Defines exact equivalence
-Interpretation
of rejection of noninferiority is obtained from examining
design
·Alt: Mean of -1 in treatment, 0 in comparison
-Limit of acceptable inferiority
S+SeqTrial: Specifying Hypotheses
