February, 2003
© 2000, 2001  Scott S. Emerson, M.D., Ph.D.
Session 2: 13
Criteria for Stopping a Trial
Statistical basis for stopping criteria
Curtailment
·Boundary has been reached early
·
·E.g., one arm study with binary endpoint
-Critical value for rejection of null might be observation of K events
·
-Kth event may occur well before all subjects accrued