Design, Monitoring, and Analysis of Clinical Trials

February, 2003

Session 2: 60

Stopping Rules

Correspondence to classical tests of H0: q = q0

·One-sided tests of greater alternative (upper and lower tests coincident)

q- < q0- = q0 (define q0+ = q- and q+ = q0-)

·One-sided tests of lesser alternative (upper and lower tests coincident)

q0 = q0+ < q+ (define q- = q0+ and q0- = q+)

·Two-sided tests

q- < q0- = q0 = q0+ < q+ (with q- = - q+ )