February, 2003
© 2000, 2001
Scott S. Emerson, M.D., Ph.D.
Computer search for
stopping boundaries
Error spending
family defines Eaj, Ebj, Ecj,
Edj
Appendix
of Kittelson and Emerson (1999) describes general algorithm for
finding design when hypotheses known
At design
stage, must search for standardized hypotheses that result in a valid
design, and then compute sample size to map standardized design to specified
alternative hypotheses.