February, 2003
© 2000, 2001
Scott S. Emerson, M.D., Ph.D.
Methods for
comparison
Find
optimal designs in terms of average sample size (ASN) within family of Wang
and Tsiatis (1987) boundary shape functions for one-sided
symmetric designs (Emerson and Fleming, 1989)
·Family found
to be approximately optimal
·
Find
optimal designs for various choices of type I error and statistical
power