February, 2003
© 2000, 2001 Scott S. Emerson, M.D., Ph.D.
Validity of flexible
determination of analysis times
Inference
conditional on actual schedule of analyses
Can
disregard rule for scheduling analyses if it is independent of measures
of treatment effect
If all
possible adaptations maintain particular operating characteristics, then
so will adaptive rule
(May affect
other operating characteristics of design)