February, 2003
© 2000, 2001 Scott S. Emerson, M.D., Ph.D.
Session 3: 16
Schedule of Analyses
Need methods that allow flexibility in determining number and timing of analyses
Should maintain some (but not, in general, all) desired operating characteristics, e.g.:
·Type I error
·Type II error
·Maximal sample size
·Futility properties
·Bayesian properties