February, 2003
© 2000, 2001 Scott S. Emerson, M.D., Ph.D.
Session 3: 26
Estimation of Statistical Information
Validity of flexible determination of sample size
Inference conditional on actual sample size
Can disregard rule for determining sample size if it is independent of measures of treatment effect
If all possible adaptations maintain particular operating characteristics, then so will adaptive rule
(May affect other operating characteristics of design)