February, 2003
© 2000, 2001 Scott S. Emerson, M.D., Ph.D.
Session 3: 35
Boundary Scales
Extensions to those parametric families in S+SeqTrial: Constrained boundaries
Motivation: Extreme conservatism of the O’Brien-Fleming design
Specify a design that has stopping boundaries that are the least extreme of an O’Brien-Fleming boundary relationship or a fixed sample P value of .001