February, 2003
© 2000, 2001 Scott S. Emerson, M.D., Ph.D.
Session 3: 48
Measuring Study Time
In either case, we must decide how we will deal with estimates of statistical information at each analysis when constraining boundaries
Statistical information in clinical trials typically has two parts
·V = variability associated with a single sampling unit
·The distribution of sampled levels of treatment
·
In many clinical trials, the dependence on the distribution of treatment levels across analyses is only on the sample size N