February, 2003
© 2000 Scott S. Emerson, M.D., Ph.D.
Session 4: 89
Data Driven Selection of Stopping Rule
Model hybrid test
Y is number of toxicities in first four patients
If Y < c, stay with fixed sample design
If Y > c, switch to group sequential test
First term computed under FST or (shifted) GST according
to value of c
