February, 2003
© 2000 Scott S. Emerson, M.D., Ph.D.
Session 4: 44
Relative Advantages
Point estimates: Spectrum of group sequential designs for which defined
(All)
Bias adjusted mean
Median unbiased with sample mean ordering UMVUE-like
Maximum likelihood estimate
(Not two-sided tests with stopping under both hypotheses)
Median unbiased with analysis time ordering