February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
In sequential testing (1 or more interim analyses), more
specialized software is necessary.
The sampling density at each stage depends on continuation
from previous stage
Recursive numerical integration of convolutions
The sampling density is not so simple: skewed, multimodal,
with jump discontinuities
The treatment effect is no longer a shift parameter