February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Frequentist Methods 1: 54
Statistical Issues
The magnitude of the effect of the stopping rule on trial design operating characteristics and statistical inference can vary substantially
Rule of thumb:
·The more conservative the stopping rule at interim analyses, the less impact on the operating characteristics and statistical inference when compared to fixed sample designs.