February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Failure to adjust the maximal sample size does affect the
power of the clinical trial design
The introduction of the stopping rule will decrease
the power of the design relative to a fixed sample design with
the same maximal sample size
In the examples considered so far, we maintained
the maximal sample size at 100 subjects