February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Phases of Clinical Trials: 2
Phases of Clinical Trials
When testing a new treatment or disease preventive regimen, phase III confirmatory studies are typically preceded by several phase I and II screening studies
·Phase I: Initial safety / dose finding
·Phase II: Preliminary efficacy / further safety
·Phase III: Establishment of efficacy
·Phase IV:
-Therapeutics:  Post-marketing surveillance
-Prevention: Effectiveness