February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Screening Studies: 8
Preliminary Studies in Screening
Scenario 1: Only large trials
10% of drugs being investigated truly work
Level of significance .05
1000 subjects provide 97.5% power to detect clinically important treatment effect
·
1,000,000 subjects available for clinical trials
·Study 1,000 new treatments
·100 effective treatments, 900 ineffective treatments