February, 2003
© 2000, 2001, 2003 Scott S. Emerson, M.D., Ph.D.
Screening Studies: 10
Preliminary Studies in Screening
Scenario 2: Use of pilot studies
10% of drugs being investigated truly work
Level of significance .05
500 subjects provide 80% power to detect clinically important treatment effect
50 subjects provide 15% power to detect clinically important treatment effect