19
Ultimate Goal
Design and analysis of clinical trials to allow quantification
of the strength of evidence for or against scientific
hypotheses
–AND
to allow concise presentation of results
Need to convince the audience, who may
–Disagree
on what are most important hypotheses
•What
precision is necessary for what endpoints?
–Disagree
on definition of statistical evidence
•Frequentist
vs Bayesian (with varying priors)