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Adaptive Sampling Plans
At each analysis of the data, the sampling plan can be modified to account for changed perceptions of possible results
•E.g., Proschan & Hunsberger (1995)
–Use conditional power considerations to modify ultimate sample size
•E.g., Self-designing Trial (Fisher, 1998)
–Prespecify weighting of groups “just in time”
•Weighting for each group only need be specified at immediately preceding analysis