87
Case Study:
 Tabled boundaries on MLE Scale
0.0418
-0.0418
1700
Time 1
Fixed Sample
-0.0496
-0.0496
1700
Time 4
-0.0419
-0.0572
1275
Time 3
-0.0290
-0.0701
850
Time 2
0.0000
-0.0991
425
Time 1
Pocock
-0.0427
-0.0427
1700
Time 4
-0.0285
-0.0570
1275
Time 3
0.0000
-0.0855
850
Time 2
0.0855
-0.1710
425
Time 1
O’Brien-Fleming
Futility
Boundary
Efficacy
Boundary
Sample Size