89
Case Study:
 Inference on the Boundaries
0.025
(-0.099, 0.000)
-0.050
-0.050
0.025
(-0.086, 0.000)
-0.043
-0.043
1700
0.029
(-0.098, 0.002)
-0.044
-0.042
0.067
(-0.079, 0.010)
-0.031
-0.029
1275
0.078
(-0.095, 0.014)
-0.035
-0.029
0.401
(-0.061, 0.044)
-0.006
0.000
850
0.371
(-0.084, 0.053)
-0.010
0.000
0.977
(0.001, 0.139)
0.077
0.086
425
Futility
0.025
(-0.099, 0.000)
-0.050
-0.050
0.025
(-0.086, 0.000)
-0.043
-0.043
1700
0.023
(-0.101, -0.001)
-0.055
-0.057
0.012
(-0.096, -0.007)
-0.054
-0.057
1275
0.018
(-0.114, -0.004)
-0.065
-0.070
0.002
(-0.130, -0.025)
-0.080
-0.086
850
0.010
(-0.152, -0.015)
-0.089
-0.099
0.000
(-0.224, -0.087)
-0.163
-0.171
425
Efficacy
P val
95% CI
Bias Adj
Estimate
MLE
P val
95% CI
Bias Adj
Estimate
MLE
N
Pocock
O'Brien-Fleming