Evaluation of Clinical Trial Designs

Grg Family

Fleming & Harrington:

•Logrank statistic: ρ=0; γ=0

•Wilcoxon statistic: ρ=1; γ=0

–Weights early differences more heavily

•“Early” defined relative to survivor function, not time

•ρ=1; γ=1

–Places greatest weight between 25th, 75th quantiles

•ρ=0; γ=1

–Weights late differences more heavily